Protein Details: Gamma-aminobutyric acid receptor subunit rho-2
Protein ID
ICDB_Pro_0536
Protein Name
Gamma-aminobutyric acid receptor subunit rho-2
Gene Name
Gabrr2
Organism
Rattus norvegicus (Rat)
Length
465 amino acids
AlphaFoldDB
AF-P47742-F1-model_v4.pdb
Function
Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA); the major inhibitory neurotransmitter in the brain. Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits; where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA; rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Rho-2 GABAARs may contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (By similarity). Rho-2 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). Rho-2 GABAARs expressed in retina may play a role in retinal neurotransmission.
Sequence
PDB Structures
Ligand Binding
Binding Site
BINDING 105; /ligand="4-aminobutanoate": "ligand shared between two neighboring rho subunits"; /note="in chain A"; BINDING 169; /ligand="4-aminobutanoate": "ligand shared between two neighboring rho subunits"; /note="in chain A"; BINDING 197; /ligand="4-aminobutanoate": "ligand shared between two neighboring rho subunits"; /note="in chain B";
Disease
Location
Expressed in spinal cord and in cerebellum (PubMed:7643126). Expressed in retina (PubMed:7643126).
DOI ID
10.1046/j.1471-4159.1995.65030964.x; 10.1073/pnas.92.25.11756; 10.1074/jbc.m205162200
RefSeq
NP_058988.1 [P47742-1]